Kratom enthusiasts have long been mystified by the chemical ‘7-hydroxymitragynine’, which is found primarily in the Kratom leaf. Information about this chemical was difficult to gather in the past. Today science has evolved to a point where not only have these chemicals been identified, but even the tiniest details are known about them! 7-hydroxymitragynine is one of the two most important alkaloids present inside Kratom and is often referred to as 7-OH. The quantity of this alkaloid is fairly limited in all Kratom leaves, but that does not decrease the importance of 7-hydroxymitragynine one bit. Read on to learn more about this intriguing alkaloid and also the Kratom strains. Find out which has the highest concentration of 7-hydroxymitragynine in them.

Composition of 7-hydroxymitragynine

7-hydroxy mitragynine natural

7-OH or 7-hydroxymitragynine is considered the oxidized derivative of Mitragynine. It is the primary alkaloid found in Kratom leaves. It was first described officially in 1994. The structure of 7-OH is similar to Mitragynine, except for the additional hydroxyl group. 7-hydroxymitragynine is thought to be a natural product of the Mitragynine metabolized in the Kratom tree. It occurs because of auto-oxidation of Mitragynine to 7-hydroxymitragynine. The total alkaloid concentration in dried Kratom leaves ranges from 0.5-1.5%. In most varieties, the majority of this percentage consists of Mitragynine, whereas 7-OH accounts for around 2% of the Kratom plant’s alkaloid content. However, it is considered the special mysterious element in Kratom plants. It is the reason that Kratom varieties have different properties.

Studies have shown that the mu-opioid receptor activity of 7-hydroxymitragynine comes to a halt when small alterations are made to the acrylate and ethyl groups on one of the rings. We also discovered that the average 7-OH concentration in Kratom products is about 0.11/0.39 mg/g respectively. However, Kratom resins in Japan contained about 0.12/0.37 mg/g of 7-hydroxymitragynine. The molecular weight of 7-hydroxymitragynine is reported to be 414.5g/mol.

Chemical Formula

Looking at the scientific aspect of things can often be boring and monotonous. However, they will help you to truly understand all the mysteries that are associated with the Mitragyna Speciosa tree. The science behind the tree and its chemicals are what produces this mystery in the first place. Having said that, let’s look at the scientific name of the chemical we all know as 7-hydroxymitragynine. The name assigned to it is  ‘(αE,2S,3S,7aS,12bS)-3-ethyl-1,2,3,4,6,7,7a,12b-octahydro-7a-hydroxy-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid methyl ester’ whereas the molecular formula of 7-OH is stated as C23H30N2O5.

Other Alkaloids in Kratom 

7-hydroxy mitragynine alkaloid

You may have only heard about 2 of the most prominent alkaloids present in the Kratom leaves, but did you know that there are about 40 other bioactive compounds, 25 of which are alkaloids, present? The principal alkaloids inside these Kratom leaves contain 7-hydroxymitragynine, Mitragynine, Speciociliatine, Speciogynine, and Paynantheine. The differences these alkaloids can cause in the Kratom leaves varies depending on several factors. These include changes in the proportion of the alkaloid compounds present, the geographic region it was grown in, stage of maturity, and ecotype.

Studies have also shown that because these plants are grown in different regions, they might even have some additional alkaloids that are not present in other types of Kratom. One example of this can be found in some versions of the Thai Kratom plant, which have distinct alkaloid profiles, while some had many additional alkaloids that no other Kratom strain possesses. Another example is found in one of the Malay Kratom plants, which contained Mitragynine, Speciofoline, and other indoles and oxindoles.

Before the 1990s, it was believed that Mitragynine was the principal alkaloid present in the Kratom plant. Later, research showed that 7-hydroxymitragynine was the principal alkaloid that gave Kratom plants their most distinct properties. Since 7-hydroxymitragynine is a direct derivative of Mitragynine, it is essential to learn a little about Mitragynine as well. It is the most commonly found and abundant alkaloid in the Kratom leaves. It was first discovered in 1921; however, its chemical structure was properly explained in 1964.

The scientific name given to Mitragynine is ‘(αE,2S,3S,12bS)-3-ethyl-1,2,3,4,6,7,12,12b-octahydro-8-methoxy-α-(methoxymethylene)-indolo[2,3-a]quinolizine-2-acetic acid methyl ester’. Some other names that are also associated with Mitragynine are; (E)-16, 17-didehydro-9, 17-dimethoxy-17, 18-seco-20α-yohimban-16-carboxylic acid methyl ester, 9-methoxy corynantheidine, and SK&F 12711.

Origin of Kratom and Its Different Types

The dried Kratom leaf is sold in different forms on the internet and retail shops all over the world. It has originated from the Mitragyna Speciosa tree that is commonly found in the South Asian region in countries like Indonesia, Malaysia, Thailand, etc. This tree is generally 4-16 meters tall and belongs to the same tree family as the coffee tree. Because of its plant-like shape, many people make the mistake of assuming it to be a plant rather than a tree. The leaves of this tree primarily adopt three different colors, which are based on the stage of maturity they are in.

Want to know more? Read our blog on the subject: what is kratom?

The youngest leaves are called Green vein Kratom, after which the leaf matures into White-vein Kratom. The final stage of maturity that the leaf adopts is known as Red vein Kratom, and usually, this stage of maturity has the highest number of alkaloids present. One thing that many Kratom enthusiasts are unaware of is the fact that the color of the Kratom leaves can only be determined by looking at their vein colors.

Since the South Asian regions provide the best conditions to grow the Kratom tree, it is thought that the Kratom obtained from these areas are of the highest quality. Each strain is different from the other, and this gives Kratom enthusiasts all over the world a range of options when it comes to choosing what Kratom strain they want. Furthermore, Kratom is available in several different forms. This makes the act of buying Kratom even more fun for all Kratom enthusiasts! Some of the most popular forms that Kratom is available throughout the world today are:

If you want to read more, you can find the best kratom strains and types here.

Most Popular Kratom Strains 

The color that is associated with the highest alkaloid concentration is the Red-veined Kratom. The Red-veined strains have long been very popular amongst Kratom buyers all over the world. For the most recurring buyers, it is the recommended one. The reason for this is because the Red-veined Kratom strains have the highest percentage of 7-hydroxymitragynine in comparison to the other two colors. Other colors can also possess high levels of 7-OH, but for the Red-vein color, it just comes naturally and without too much effort.

If you are looking to buy Kratom with a high amount of 7-OH, here are some strains in the red-vein category that are considered the most popular by Kratom enthusiasts:

Bali Kratom:

Bali Kratom has gotten its name from the Indonesian island of Bali, and today it is grown in different regions of Thailand and Malaysia. It’s known to be the fastest-growing strain and the easiest to produce. Its low price and high alkaloid concentration make it a top pick for Kratom buyers all over the world.

Maeng Da Kratom:

Maeng Da Kratom is thought to have originated from the regions of Indonesia and Thailand. It is considered to be a very high-quality strain available.

Borneo Kratom:

The Borneo Kratom strain is named after the island of Borneo. Because of its high levels of 7-hydroxymitragynine, it is a top contender for any Kratom enthusiast.

Tweaking of Alkaloid Levels in Kratom Products

Not all vendors in the Kratom business care about their customers as much as we do at Buy Kratom Bulk USA. For some, making the highest percentage of profit is the highest agenda. To achieve this, they will look to purchase the cheapest Kratom possible and then sell it at a high price point to their customers. Because of this, customers often end up getting low-quality Kratom that leaves them unsatisfied.

There is, however, something even more alarming that is taking place in the Kratom industry! A handful of vendors have found a way to enhance the properties of their Kratom by adding extra amounts of 7-hydroxymitragynine to their Kratom! By doing this, they are enhancing the alkaloid concentration levels of the Kratom strain but they have to label it as such. Also, adding ingredients to the Kratom strains can change the characteristic properties of that particular kratom product.

Where to Safely Buy Kratom

With such unethical practices going on in the Kratom world, you must choose top-quality vendors to obtain your Kratom from. If you are worried about where you will find such top-quality vendors, then you should stop and rest easy because you have already found us! At Buy Kratom Bulk USA, customer satisfaction is our priority, and for this, we have obtained our Kratom directly from the experts down in South Asia. Just give our homepage a visit and take a look at all the top-quality Kratom for sale we have available for you!

Or you can also read our detailed guide on where to buy kratom online!

Final Words

There are a variety of alkaloids that are present inside the Kratom leaf; however, information is easily available on only two of them because of the lack of research in this area. As Kratom grows in popularity, enthusiasts all over the world are looking to learn more and more about Kratom. Luckily, some brilliant minds all have gathered together to find out more about the mysteries behind the fabulous Kratom tree.

To learn more about these mysteries, make sure to visit our Kratom blogs section.Alkaloid 7-hydroxy mitragynine


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